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Category Archives: Gene therapy
A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures.
Authors: Turrell SJ, Macnab SA, Rose A, Melcher AA, Whitehouse A Abstract Herpesvirus saimiri (HVS) is capable of infecting a range of human carcinoma cell types with high efficiency and the viral genome persists as high copy number, circular, non-integrated … Continue reading
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Calcium carbonate microparticles used as a gene vector for delivering p53 gene into cancer cells.
In this study, CaCO(3) delivering pEGFP-C1-p53 could transfect about 5% of the tumor cells in culture. However, the efficiency of tumor cell apoptosis was surprisingly up to 80%. Meanwhile, the results of MTT assay and crystal violet staining showed that … Continue reading
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A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications
Molecular imaging is revolutionizing the way we study the inner workings of the human body, diagnose diseases, approach drug design, and assess therapies. The field as a whole is making possible the visualization of complex biochemical processes involved in normal … Continue reading
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Adeno-associated virus-mediated doxycycline-regulatable TRAIL expression suppresses growth of human breast carcinoma in nude mice
Conclusion: These data suggest that rAAV-mediated soluble TRAIL expression under the control of the Tet-On system is a promising strategy for breast cancer therapy. (Source: BMC Cancer)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
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Gene Therapy Part 1 – Video
25-04-2012 11:32 A teaching project for the 2012 Student Bio Expo by Grifynn Clay. A brief introduction to gene therapy in relationship to genetic mutations. Continue reading
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Tagged brief-introduction, for-the, gene-therapy, genetic-mutations-, grifynn, grifynn-clay-, student, teaching-project
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Will we ever correct diseases before birth? | Not Exactly Rocket Science
Heres the sixth piece from my new BBC column Every year, millions of people are born with debilitating genetic disorders, a result of inheriting just one faulty gene from their parents. Continue reading
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Tagged a-cell-with, a-dud-genetic, a-little-bit, bbc, british, diseases, genes, power, research, safety, several-british, such-as-airways, university, with-the-genes, womb
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Parkinson's victim hails therapy
Parkinson’s victim hails therapy 7:10pm Monday 23rd April 2012 in News A woman with Parkinsons disease can write for the first time in 15 years after receiving gene therapy developed by an Oxford company. Sheila Roy, 57, is one of only 15 people worldwide to undergo the treatment developed by Oxford Biomedica, which involves injecting corrective genes into the brain. She has had the disease for 17 years, and now has severe tremors and loss of balance, making simple tasks like writing impossible Continue reading
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Tagged bedfordshire, biomedicas, disease, early-study-, facility-later, into-the-brain, now-starting, oxford, parkinsons, receiving-gene, results-were
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Research and Markets: Recent Advances in Cancer Research and Therapy – Increased Research on one of the Major Causes …
DUBLIN–(BUSINESS WIRE)– Research and Markets (http://www.researchandmarkets.com/research/msjp88/recent_advances_in) has announced the addition of Elsevier Science and Technology’s new report “Recent Advances in Cancer Research and Therapy” to their offering. Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments Continue reading
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Tagged book, chinese, field, liposome-based, markets, research, targeted-gene, technology, therapy, topics-covered
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Amsterdam Molecular Therapeutics Receives Further Opinion on Glybera® Marketing Authorisation Application
AMSTERDAM, The Netherlands, April 23, 2012 /PRNewswire/ — Amsterdam Molecular Therapeutics (AMT) Holding N.V. (in liquidatie) (Euronext: AMT – News), a leader in the field of human gene therapy, has received notice that the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has maintained its earlier opinion that Glybera (alipogene tiparvovec) is not approvable at this time Continue reading
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Tagged a-has-orphan, a-treatment-for, advice, advisory-group, amsterdam, blood, cat, european, experts, glybera, majority, netherlands, safety, scientific, time
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Global Gene Therapy Industry
NEW YORK, April 16, 2012 /PRNewswire/ — Reportlinker.com announces that a new market research report is available in its catalogue: Global Gene Therapy Industry http://www.reportlinker.com/p098244/Global-Gene-Therapy-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=BiologicaThis …Source:http://news.search.yahoo.com/news/rss?ei=UTF-8&p=gene+therapy&eo=UTF-8
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Treatment of a Solid Tumor Using Engineered Drug-Resistant Immunocompetent Cells and Cytotoxic Chemotherapy
Human Gene Therapy , Vol. 0, No. 0. (Source: Human Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
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Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice
On antigen binding by the B-cell receptor (BCR), B cells up-regulate protein expression of the key downstream signaling molecule Bruton tyrosine kinase (Btk), but the effects of Btk up-regulation on B-cell function are unknown. Here, we show that transgenic mice … Continue reading
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Innovative Methods for Improving Measures of the Personal Environment
A popular adage in thinking about disease risk states that “your genes may load the gun, but your environment pulls the trigger.” Nearly a decade following the completion of the Human Genome Project, it is clear that genetic variation is … Continue reading
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Potent systemic therapy of multiple myeloma utilizing oncolytic vesicular stomatitis virus coding for interferon-?
Potent systemic therapy of multiple myeloma utilizing oncolytic vesicular stomatitis virus coding for interferon-β Cancer Gene Therapy advance online publication, April 20, 2012. doi:10.1038/cgt.2012.14 Authors: S Naik, R Nace, G N Barber & S J Russell (Source: Cancer Gene Therapy) … Continue reading
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Treatment of adult MPSI mouse brains with IDUA-expressing mesenchymal stem cells decreases GAG deposition and improves exploratory behavior
Conclusions: These data show that gene therapy, via the direct injection of IDUA-expressing MSCs into the brain, is an effective way to treat neurodegeneration in MPSI mice. (Source: Genetic Vaccines and Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
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Direct conversion in the heart: a simple twist of fate
This study hints that a gene therapy approach for in-situ reprogramming may provide an alternative for generating new cardiomyocytes within failing hearts. (Source: The EMBO Journal AOP)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
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[World Report] Promising new era dawns for cystic fibrosis treatment
The recent approval of a new drug and the start of a phase 2 gene therapy trial are creating excitement about future treatment possibilities for people with cystic fibrosis. Zöe Corbyn reports. (Source: LANCET)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
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British Society for Gene Therapy 2012; March 9, 2012; UCL Institute of Child Health, London
Human Gene Therapy , Vol. 0, No. 0. (Source: Human Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
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Lab Notes: Skin Cancer Spread Tied to Gene
(MedPage Today) — Targeted gene therapy might help stop the spread of melanoma metastases, in this week’s Lab Notes. Also, how can yeast help with depression and a quick fix for cocaine OD. (Source: MedPage Today Cardiovascular) MedWorm Sponsor Message: … Continue reading
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